人 AKT1 (NM_005163) cDNA克隆

Accession: NM_005163
基因名称: AKT1
基因别名: AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
基因描述: Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1443 (查看编码区序列)
翻译后氨基酸长度: 480 (查看氨基酸序列)
Transcript Variant: This variant (1) is the longest transcript. Variants 1, 2 and 3 encode the same protein.
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G106839 人 AKT1 (NM_005163) cDNA克隆 pDONR223 2ug质粒 点击询价

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]