人 IKZF3 (NM_012481) cDNA克隆

Accession: NM_012481
基因名称: IKZF3
基因别名: AIO; AIOLOS; ZNFN1A3
基因描述: Homo sapiens IKAROS family zinc finger 3 (Aiolos) (IKZF3), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1530 (查看编码区序列)
翻译后氨基酸长度: 509 (查看氨基酸序列)
Transcript Variant: This variant (1) encodes the longest isoform (1, also known as Aio-1).
产品编号 产品名称 载体 规格 价格
G111883 人 IKZF3 (NM_012481) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]