人 IKZF3 (NM_001284514) cDNA克隆

Accession: NM_001284514
基因名称: IKZF3
基因别名: AIO; AIOLOS; ZNFN1A3
基因描述: Homo sapiens IKAROS family zinc finger 3 (Aiolos) (IKZF3), transcript variant 14, mRNA.
种属: Human
CDS区长度: 789 (查看编码区序列)
翻译后氨基酸长度: 262 (查看氨基酸序列)
Transcript Variant: This variant (14) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (14) with a shorter N-terminus, compared to isoform 1. Variants 14, 15, and 16 encode the same isoform (14).
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G111896 人 IKZF3 (NM_001284514) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]