人 IKZF3 (NM_001257414) cDNA克隆

Accession: NM_001257414
基因名称: IKZF3
基因别名: AIO; AIOLOS; ZNFN1A3
基因描述: Homo sapiens IKAROS family zinc finger 3 (Aiolos) (IKZF3), transcript variant 13, mRNA.
种属: Human
CDS区长度: 1128 (查看编码区序列)
翻译后氨基酸长度: 375 (查看氨基酸序列)
Transcript Variant: This variant (13) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (13, also known as Aio-del4,5,6) has the same N- and C-termini but is shorter compared to isoform 1.
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G111895 人 IKZF3 (NM_001257414) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]