人 RCHY1 (NM_001009922) cDNA克隆

Accession: NM_001009922
基因名称: RCHY1
基因别名: ARNIP; CHIMP; PIRH2; RNF199; ZNF363; PRO1996
基因描述: Homo sapiens ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase (RCHY1), transcript variant 3, mRNA.
种属: Human
CDS区长度: 759 (查看编码区序列)
翻译后氨基酸长度: 252 (查看氨基酸序列)
Transcript Variant: This variant (3) lacks an in-frame exon in the internal coding region, compared to variant 1. The encoded isoform (3, also known as Pirh2B) is shorter, compared to isoform 1.
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G115446 人 RCHY1 (NM_001009922) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]