人 RCHY1 (NM_001278539) cDNA克隆

Accession: NM_001278539
基因名称: RCHY1
基因别名: ARNIP; CHIMP; PIRH2; RNF199; ZNF363; PRO1996
基因描述: Homo sapiens ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase (RCHY1), transcript variant 9, mRNA.
种属: Human
CDS区长度: 405 (查看编码区序列)
翻译后氨基酸长度: 134 (查看氨基酸序列)
Transcript Variant: This variant (9) uses an alternate splice site in the 5' terminal exon, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (7) has a shorter N-terminus, compared to isoform 1.
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G115451 人 RCHY1 (NM_001278539) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]