人 ACVR2A (NM_001278579) cDNA克隆

Accession: NM_001278579
基因名称: ACVR2A
基因别名: ACVR2; ACTRII
基因描述: Homo sapiens activin A receptor, type IIA (ACVR2A), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1542 (查看编码区序列)
翻译后氨基酸长度: 513 (查看氨基酸序列)
Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
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G119620 人 ACVR2A (NM_001278579) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]