人 NCOA3 (NM_006534) cDNA克隆

Accession: NM_006534
基因名称: NCOA3
基因别名: ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
基因描述: Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 2, mRNA.
种属: Human
CDS区长度: 4263 (查看编码区序列)
翻译后氨基酸长度: 1420 (查看氨基酸序列)
Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
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G122633 人 NCOA3 (NM_006534) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]