人 ABCC9 (NM_005691) cDNA克隆

Accession: NM_005691
基因名称: ABCC9
基因别名: SUR2; ABC37; CANTU; CMD1O; ATFB12
基因描述: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant SUR2A, mRNA.
种属: Human
CDS区长度: 4650 (查看编码区序列)
翻译后氨基酸长度: 1549 (查看氨基酸序列)
Transcript Variant: This variant (SUR2A) uses an alternate 3' coding exon (exon 38A), compared to variant SUR2B, which uses exon 38B. The encoded isoform (SUR2A) has an alternate 38-amino acid C-terminus, but is the same length as isoform SUR2B. There are no full-length transcripts representing this variant in human; it is supported by partial transcript alignments, by full-length transcript alignments from the homologous mouse and rat genes, and by RT-PCR analysis in PMID:11054556.
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G105004 人 ABCC9 (NM_005691) cDNA克隆 pDONR223 2ug质粒 点击询价
人 ABCC9 (NM_005691) cDNA克隆 transcript variant SUR2A
人 ABCC9 (NM_020297) cDNA克隆 transcript variant SUR2B

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]