人 ABCC11 (NM_145186) cDNA克隆

Accession: NM_145186
基因名称: ABCC11
基因别名: WW; EWWD; MRP8
基因描述: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 11 (ABCC11), transcript variant 3, mRNA.
种属: Human
CDS区长度: 4035 (查看编码区序列)
翻译后氨基酸长度: 1344 (查看氨基酸序列)
Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
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G112222 人 ABCC11 (NM_145186) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]