人 ABCC1 (NM_004996) cDNA克隆

Accession: NM_004996
基因名称: ABCC1
基因别名: MRP; ABCC; GS-X; MRP1; ABC29
基因描述: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1), mRNA.
种属: Human
CDS区长度: 4596 (查看编码区序列)
翻译后氨基酸长度: 1531 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G152637 人 ABCC1 (NM_004996) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]